"Patience is a Super Power" - "The Money is in the waiting"

Monday, June 2, 2025

Income and Capital appreciation are the two aims of The Amplify CWP Enhanced Dividend Income ETF (DIVO)

 


The Amplify CWP Enhanced Dividend Income ETF (DIVO) is an actively managed exchange-traded fund designed to provide investors with a combination of current income and capital appreciation. It achieves this through a strategic blend of high-quality, dividend-paying U.S. equities and a tactical covered call options strategy.Amplify ETFs


📌 Fund Overview


💰 Income & Yield

DIVO's income is derived from dividends of its underlying equity holdings and premiums collected from writing covered call options. This combination aims to provide a steady income stream for investors.


📊 Performance Snapshot

These returns reflect DIVO's strategy of balancing income generation with potential for capital growth, making it appealing to investors seeking a blend of both.


🧠 Investment Strategy

DIVO focuses on investing in high-quality, large-cap U.S. companies with a history of dividend and earnings growth. The fund's sub-adviser, Capital Wealth Planning (CWP), employs a tactical covered call strategy, writing call options on individual stocks within the portfolio when market conditions are favorable. This approach aims to enhance income without significantly sacrificing upside potential.Morningstar+2Amplify ETFs+2MarketWatch+2


🏢 Top Holdings (as of May 29, 2025)

CompanyTickerWeight
Invesco Government & Agency PortfolioAGPXX8.04%
Visa Inc.V5.23%
IBMIBM4.99%
CME Group Inc.CME4.98%
The Home Depot, Inc.HD4.93%
JPMorgan Chase & Co.JPM4.89%
The Goldman Sachs Group, Inc.GS4.82%
American Express CompanyAXP4.55%
Microsoft CorporationMSFT4.53%
Honeywell International Inc.HON4.41%

These holdings reflect DIVO's emphasis on financially robust companies across various sectors.


🧭 Suitability

DIVO may be suitable for investors seeking:

  • Consistent monthly income

  • Exposure to high-quality, dividend-paying U.S. equities

  • A tactical approach to covered call writing

  • Potential for capital appreciation alongside incomeAmplify ETFs

However, investors should be aware that the fund's use of covered calls can limit upside potential in strongly bullish markets. Additionally, the fund's performance is subject to market risks associated with its equity holdings.

Saturday, May 31, 2025

Here's an aggressive way to enter the Agentic Ai stock race if you're seeking high reward that carries high risk!

 


here's a high-conviction Agentic AI stock watchlist for an aggressive portfolio, including ideal buy ranges, key catalysts, and what to watch for each company. This is geared toward catching breakouts or deep-value setups before broader institutional moves.


🔧 AGENTIC AI CREATORS (BUILDERS)

1. C3.ai (Ticker: AI)

  • Ideal Buy Range: $22 – $28

  • Catalyst to Watch:

    • New generative AI enterprise product launches (esp. AI agents for defense/oil & gas)

    • Major U.S. government contract renewals or expansions

  • Why it’s on the list: First-mover advantage in enterprise AI platforms; if execution improves, the upside is enormous.


2. Symbotic (Ticker: SYM)

  • Ideal Buy Range: $33 – $38

  • Catalyst to Watch:

    • New mega-retailer partnerships (Amazon, Target, etc.)

    • Expansion into full-agentic warehouse orchestration

  • Why it’s on the list: Already profitable and scaling; its tech uses autonomous decision-making across supply chains.


3. Recursion Pharmaceuticals (Ticker: RXRX)

  • Ideal Buy Range: $5.50 – $7.50

  • Catalyst to Watch:

    • New AI-discovered drug candidates entering clinical trials

    • Further expansion of NVIDIA partnership

  • Why it’s on the list: One of the few companies using AI agents to autonomously identify disease-drug interactions.


🚀 AGENTIC AI BENEFICIARIES (ADOPTERS)

4. Tempus AI (Ticker: TEM)

  • Ideal Buy Range: $30 – $36 (as a new IPO, use limit orders around pullbacks)

  • Catalyst to Watch:

    • Major hospital system deals

    • Partnerships with genomic leaders (e.g. Illumina, Roche)

  • Why it’s on the list: Early innings of precision medicine + AI agents = potentially massive future upside.


5. Axon Enterprise (Ticker: AXON)

  • Ideal Buy Range: $275 – $295

  • Catalyst to Watch:

    • Release of AI-powered real-time monitoring or predictive tools

    • Federal/DoD AI safety tech contracts

  • Why it’s on the list: Dominates public safety; building autonomous surveillance systems in-house.


6. Samsara (Ticker: IOT)

  • Ideal Buy Range: $30 – $34

  • Catalyst to Watch:

    • Launch of AI co-pilots or agents for fleet automation

    • Expansion into non-logistics industries (e.g. construction, food supply)

  • Why it’s on the list: Already uses agentic loops for logistics and safety — sticky B2B model with scale potential.


📋 Summary: Watchlist Snapshot

TickerNameIdeal Buy RangeKey Catalyst
AIC3.ai$22–$28New enterprise AI agents/contracts
SYMSymbotic$33–$38Expansion into new retail/logistics
RXRXRecursion$5.50–$7.50Drug pipeline + Nvidia push
TEMTempus AI$30–$36Genomics/healthcare expansion
AXONAxon$275–$295AI-enabled law enforcement tools
IOTSamsara$30–$34AI co-pilot expansion to new verticals

Ed Note:

We own several of the stocks listed here with the rest on our watch list!

Thursday, May 29, 2025

Here is a list of cutting edge, smallcap biotech stocks we own and in order!

 


Generative AI is transforming healthcare faster than almost any other sector, according to a new McKinsey report

Here is a ranked analysis of cutting edge healthcare/pharmaceutical smallcaps, based on (1) proximity to a breakout therapy and (2) investment attractiveness as of now — combining clinical pipeline momentum, FDA progress, partnerships, recent data, and stock performance potential.


🔬 Ranked by Breakout Therapy Proximity

This is based on the likelihood of a near-term breakthrough therapy (FDA fast-track, pivotal results, major data readouts).

RankTickerCompanyBreakout Potential Highlights
1VKTXViking TherapeuticsBreakthrough obesity/NASH drug (VK2809, VK2735) with massive upside in GLP-1/obesity boom. Phase 2 data strong; entering late-stage.
2CABACabaletta BioAutoimmune pipeline (CABA-201) showing transformative early results in lupus and other autoimmune diseases. Similar strategy to CAR-T, now with safety upside.
3NTLAIntellia TherapeuticsIn vivo CRISPR for ATTR and hereditary angioedema (HAE). First-ever systemic CRISPR success in humans. Pivotal trials advancing.
4CRSPCRISPR TherapeuticsExa-cel approved for SCD and TDT (partnered with Vertex); potential for next-gen CRISPR 2.0 programs. Already a breakout, but priced in.
5BEAMBeam TherapeuticsBase editing platform; BEAM-101 for SCD in Phase 1/2; AATD candidate recently dosed. Long runway but slower than CRISPR/NTLA.
6VERVEVerve TherapeuticsBase editing for cardiovascular diseases (e.g. PCSK9, ANGPTL3). First-in-human data still early, but long-term potential.
7ARCTArcturus TherapeuticsSelf-amplifying mRNA platform. Has vaccine deals (Meiji, CSL) and cystic fibrosis program in preclinical. Earlier stage, undervalued.
8PHATPhathom PharmaceuticalsGastrointestinal therapies (e.g. Vonoprazan) targeting acid-related disorders. Recently got FDA approval — modest market.
9IMMXImmix BiopharmaEarly-stage oncology and rare disease company. Some interesting candidates, but very speculative at this point.

💰 Ranked by Investment Attractiveness Right Now

Factoring in upside potential, stock price discount, market trends (GLP-1s, gene editing), and partnerships.

RankTickerReasons to Consider Buying Now
1VKTXBest GLP-1/NASH play outside of LLY/NVO. Stock is below recent highs. Phase 3 path = massive upside.
2CABAAutoimmune breakthrough potential. Stock pulled back after big run = possible entry. Partnered with BMS.
3NTLAUndervalued after pullback; ATTR and HAE pipeline solid. First-mover advantage in in vivo editing.
4ARCTUndervalued RNA tech with global partners. COVID mRNA success + pipeline optionality.
5CRSPAlready approved drug; priced in, but pipeline optionality and Vertex partnership still strong.
6BEAMLong-term value play. Base editing unique, but needs human data.
7PHATRevenue coming in from recent approvals, but upside more limited. Good as a value biotech.
8VERVEPromising pipeline, but long timeline. Recent safety setbacks = wait for reentry.
9IMMXPure speculation. If investing, do so in very small amounts or avoid unless speculative appetite is high.

🧪 Conclusion – Top 3 Right Now:

  1. VKTX – Leading obesity/NASH contender; huge upside, fast-moving.

  2. CABA – Emerging autoimmune disruptor; next-gen cell therapy.

  3. NTLA – First-in-class CRISPR success; attractive valuation now.

Here’s a suggested portfolio weighting if you're investing across these nine biotech stocks, with emphasis on balancing breakthrough potential, clinical proximity, market trends (e.g., GLP-1/NASH, gene editing), and risk-adjusted upside:


🎯 Suggested Portfolio Allocation (100%)

TickerCompanyWeight (%)Rationale
VKTXViking Therapeutics22%Flagship position. Strong GLP-1/NASH pipeline with large-market potential and near-term catalysts.
CABACabaletta Bio18%High-upside autoimmune play. Early but transformative CAR-T-like therapy with major big pharma interest.
NTLAIntellia Therapeutics15%First-in-human systemic CRISPR success; undervalued after pullback; strong ATTR/HAE path.
CRSPCRISPR Therapeutics12%Approved therapy (Exa-cel) + broad pipeline. Still solid but partially priced in.
ARCTArcturus Therapeutics10%Undervalued RNA tech; good optionality via partnerships and CF/mRNA platforms.
BEAMBeam Therapeutics8%Base editing pioneer; longer-term play with promising science but needs more human data.
VERVEVerve Therapeutics6%Base editing in heart disease = big TAM, but safety setbacks suggest caution for now.
PHATPhathom Pharmaceuticals5%Recently approved drug, small but growing market; value-oriented slice.
IMMXImmix Biopharma4%High-risk/high-reward microcap. Small speculative exposure only.

🧠 Notes:

Tuesday, May 27, 2025

Cabaletta Bio (CABA) is a microcap stock with a serious pipeline in the Healthcare field, and a possible takeover target. Read on...

 


Cabaletta Bio Might See a Takeover Offer in the Near Future

Date: May 27, 2025
Ticker: NASDAQ: CABA
Sector: Biotechnology
Market Cap: ~$150M
Current Share Price: ~$1.75


Executive Summary

Cabaletta Bio has rapidly emerged as a key innovator in cell therapies for autoimmune diseases. With promising clinical data, regulatory tailwinds, a strategic manufacturing buildout, and growing institutional interest, the company may soon become a prime takeover candidate. As large pharmaceutical and biotech players intensify their push into immunology and autoimmune markets, Cabaletta’s lead program, rese-cel, positions the company as an attractive bolt-on acquisition for firms seeking late-stage clinical assets with scalable manufacturing platforms.


1. Clinical Breakthroughs: A Deep Pipeline in Autoimmune Therapies

Cabaletta’s lead therapy, resecabtagene autoleucel (rese-cel), is a CD19-targeting CAR-T cell therapy intended to "reset" the immune system in patients with serious autoimmune conditions. Rese-cel has already shown efficacy across multiple indications:

  • Myositis: RMAT designation received; BLA submission anticipated in 2027.

  • SLE and Lupus Nephritis: Patients achieved full remission and renal response; all are off immunosuppressants and steroids.

  • Systemic Sclerosis (SSc): Early patient data show improved skin and lung function.

  • Myasthenia Gravis (MG) and Multiple Sclerosis (MS): Clinical trials underway; FDA has granted Fast Track status for MS.

Safety Profile: Rese-cel has a highly favorable profile, with >90% of patients experiencing mild (grade 1 or lower) cytokine release syndrome, and no severe neurological toxicity reported.


2. Strategic Manufacturing Partnerships Add Scalability

Cabaletta is not only advancing in the clinic but also ensuring future commercial readiness:

  • Lonza Agreement: Expanded clinical manufacturing capabilities.

  • Cellares Partnership: Successfully validated automated manufacturing of rese-cel using the Cell Shuttle™ platform. This makes the production of CAR-T therapies more scalable and cost-effective—an attractive feature for potential acquirers.


3. Strong Institutional Confidence

  • Vanguard, Prudential Financial, and Walleye Capital significantly increased their stakes in late 2024 and early 2025.

  • Such heavyweights rarely invest in micro-cap biotech without seeing long-term upside or M&A potential.

  • Despite reduced holdings by Fred Alger Management, overall institutional sentiment remains bullish.


4. Upcoming Catalysts That May Trigger Acquisition Interest

  • June 2025: Key clinical results to be presented at the EULAR Congress.

  • H2 2025: FDA meetings to discuss registrational trials in SLE, LN, and SSc.

  • 2027: Target BLA submission for rese-cel in myositis—a potentially pivotal milestone that accelerates valuation.

These catalysts, if positive, could pressure potential buyers to move early, while CABA remains undervalued.


5. Financial Position: Runway Through 1H 2026

  • Cash on hand (as of Dec 2024): $164M

  • This provides ample time for clinical execution without dilution, enhancing the appeal to potential acquirers.


6. Why a Takeover May Be Imminent

Cabaletta’s profile aligns with key acquisition criteria:

  • Late-stage lead asset with early regulatory designations (RMAT, Fast Track).

  • Broad multi-indication applicability across lucrative autoimmune markets.

  • Scalable and automated manufacturing platforms.

  • Positive early safety and efficacy data across several trials.

  • Institutional backing from long-term investors.

  • A depressed market valuation, with shares down ~85% from peak levels.

Potential Suitors:
Large immunology players and gene/cell therapy leaders like:

  • Gilead Sciences (Kite)

  • Roche/Genentech

  • Bristol-Myers Squibb

  • Sanofi or Novartis (expanding in CAR-T and autoimmunity)


Valuation Snapshot

MetricValue (Approx)
Market Cap$150M
Cash Position$164M
52-Week High$13.50
Current Price (May 27, 2025)~$1.75
Analyst Avg. Target Price$20.08
Price/Book Ratio<1 (undervalued)

Conclusion: A Compelling Acquisition Target

Cabaletta Bio stands at the intersection of scientific innovation and unmet medical need. Its autoimmune-focused CAR-T program, strong safety/efficacy signals, and scalable production model present an ideal acquisition case. With near-term catalysts approaching and larger biopharma players under pressure to replenish pipelines, a takeover offer could materialize in the near future.

Investment Outlook: Speculative Buy with Acquisition Upside

Related posts:

Been adding to CABA Bio stock this month. Here's why!







Monday, May 26, 2025

As genetic medicine technology continues to advance, we own both BEAM and CRSPR for their cutting edge tech!



Business & Investment Report: 

Combined Investment Strategy in Beam Therapeutics (BEAM) and CRISPR Therapeutics (CRSP)


Executive Summary: Beam Therapeutics and CRISPR Therapeutics are at the forefront of gene editing, offering complementary but distinct technologies with transformative medical potential. Investing in both provides a blended exposure to early-stage innovation and commercialized gene therapies. This report outlines the rationale for a combined investment, technological differences, clinical advances, and projected value for the healthcare sector.


1. Company Overview

Beam Therapeutics (NASDAQ: BEAM)

  • Specializes in base editing, a refined form of CRISPR technology that enables precise, single-base DNA changes without causing double-stranded breaks.

  • Early-stage pipeline with flagship candidate BEAM-302, targeting Alpha-1 Antitrypsin Deficiency (AATD).

  • Holds ~$1B in cash with clinical runway through 2027.

CRISPR Therapeutics (NASDAQ: CRSP)

  • A leader in CRISPR/Cas9-based gene editing, focused on gene knockouts and repair via double-stranded breaks.

  • First to market with an FDA- and EMA-approved gene therapy: CASGEVY (exa-cel) for sickle cell disease and beta-thalassemia.

  • Backed by strong partnerships, particularly with Vertex Pharmaceuticals.


2. Technological Comparison:       Base Editing vs. CRISPR/Cas9


FeatureBeam Therapeutics (Base Editing)CRISPR Therapeutics (CRISPR/Cas9)
MechanismPrecise base substitutions (no DNA breaks)Gene knockout/repair (via DNA cutting)
SafetyLower risk of off-target effectsHigher off-target risk; immune response possible
PrecisionSingle-base changesLarger edits or gene disruptions
Use CasesPoint mutation diseases (e.g., AATD, sickle cell)Gene knockout therapies (e.g., sickle cell, cancer)

3. Clinical Pipeline & Progress

Beam Therapeutics

  • BEAM-302 (AATD):

    • FDA-cleared IND (March 2025)

    • RMAT designation (May 2025) for potential curative single-dose therapy

    • Early Phase 1/2 data shows dose-dependent correction of AAT protein levels

  • BEAM-101 (sickle cell): preclinical

  • Expanding pipeline in liver, hematologic, and ocular genetic diseases

CRISPR Therapeutics

  • CASGEVY (Exa-cel):

    • FDA + EMA approved for sickle cell and beta-thalassemia

    • Commercial launch ongoing with Vertex (60/40 profit split)

  • CTX130 (CAR-T for renal cell carcinoma): Phase 1

  • Diabetes Program: with Vertex (VX-880, VX-264) – gene-edited pancreatic cells

  • Broad ex vivo and in vivo pipeline including oncology and regenerative medicine


4. Financials & Valuation

MetricBEAMCRSP
Market Cap~$1.4B~$5.8B
Cash Reserves~$1B~$1.6B
RevenueMinimalYes (Vertex partnership + CASGEVY)
ProfitabilityNoNo (revenue generating but not profitable)

Commentary: BEAM trades near its cash value after a 75% decline from its 2021 peak. CRSP has begun generating revenue but is still early in its commercialization phase. BEAM represents high-upside speculative value, while CRSP offers more de-risked exposure.


5. Value to the Medical Community

  • BEAM (Base Editing) offers future potential for highly specific gene correction therapies with fewer side effects—ideal for treating genetic diseases caused by single-point mutations.

  • CRSP (Cas9) brings scalable solutions to market today, with transformative therapies for blood disorders and cancer.

  • Complementary Impact: CRSP addresses urgent medical needs now; BEAM could deliver more refined, next-generation solutions in the near future.


6. Investment Rationale: Blended Strategy

Portfolio Blend Recommendation:

  • 60% CRSP: Stronger near-term catalysts and commercial success

  • 40% BEAM: High-risk/high-reward innovation with upside from BEAM-302

Why this split?

  • CRSP's 60% allocation balances the portfolio with a company already generating revenue from approved therapies, strong partnerships, and a broad, maturing pipeline. This reduces overall volatility and provides more immediate return potential.

  • BEAM's 40% allocation captures the promise of base editing, which could be transformative but remains in early human trials. With the stock trading near cash value and a strong balance sheet, it presents an attractive speculative opportunity with asymmetric upside.

Alternative Allocations:

  • Aggressive investors may tilt 60% BEAM / 40% CRSP for higher potential returns.

  • Defensive investors could consider 75% CRSP / 25% BEAM and optionally include Vertex Pharmaceuticals (VRTX) for indirect exposure.

Catalyst Watch:

  • BEAM-302 clinical updates (late 2025)

  • CASGEVY revenue performance

  • VX-880 (CRSP/Vertex) trial results for diabetes


7. Final Assessment


Investing in both BEAM and CRSP offers:

  • Diversified exposure to today’s gene editing therapies and tomorrow’s precision medicines

  • A hedge between early innovation and regulatory-approved commercialization

  • Long-term upside in a sector poised to transform medicine over the next decade

Conclusion: For investors with a multi-year horizon and an interest in healthcare disruption, a BEAM + CRSP combined portfolio is a strategic play on the future of genetic medicine. The suggested allocation strategy allows for tailored risk exposure depending on the investor’s goals and conviction in each platform’s long-term success.

June 2025

How Beam Therapeutics (BEAM) in collaboration with researchers at the University of Pennsylvania and Children’s Hospital of Philadelphia saved baby KJ



Sunday, May 18, 2025

IonQ is not only a premier quantum computing stock but also a potential linchpin of the future quantum internet.


 Investment & Business Report: IonQ, Inc. (NYSE: IONQ)

UpDate: May 18, 2025


Executive Summary

IonQ is a leader in trapped-ion quantum computing and is increasingly seen as a foundational pillar in the development of a global quantum internet. Backed by a scalable technology roadmap, deep partnerships with cloud and government agencies, and strategic acquisitions, IonQ is uniquely positioned for long-term growth in both standalone quantum computing and quantum networking.


1. Company Overview

  • Founded: 2015

  • Headquarters: College Park, Maryland, USA

  • Technology: Trapped-ion quantum computing

  • Market Cap: Approx. $6.8 billion (as of May 2025)

  • Employees: ~250


2. Technology and Innovations

Trapped-Ion Architecture

IonQ uses individually controlled ions trapped in electromagnetic fields. These qubits exhibit:

  • Long coherence times

  • High-fidelity quantum gates

  • Superior error correction potential

Modular Systems

  • Forte and Aria are rack-mounted, scalable quantum systems.

  • Forte Enterprise is designed for network deployment, positioning IonQ for distributed computing and early quantum internet integration.

Quantum Networking

  • Focused on photon-based entanglement for long-distance qubit connectivity.

  • R&D includes quantum repeaters and error-protected interconnects.

  • Recent acquisition of Qubitekk enhances IonQ’s ability to develop entangled quantum networks. Qubitekk’s work on the EPB Quantum Network—the first commercially available quantum network in the U.S.—adds practical and deployable IP.


3. Strategic Partnerships and Acquisitions

Key Partnerships:

  • Amazon Web Services (AWS) – IonQ systems accessible via Braket

  • Microsoft Azure Quantum, Google Cloud – Cloud-based availability

  • U.S. Department of Energy (DOE) and DARPA – Funded projects in quantum networking

Notable Acquisitions:

  • ID Quantique (2024) – Leader in quantum key distribution (QKD), enhancing IonQ’s quantum communication capabilities

  • Qubitekk (2025) – Pioneer in quantum networking hardware and software, with over 100 patents. Qubitekk’s team and technologies are now part of IonQ, fast-tracking the company’s networking and entanglement roadmap.

  • On May 7th 2025, IonQ Announced it's Intention to Acquire Lightsynq, Expediting Quantum Computing, Quantum Internet, and Offering Clear Path to Millions of Qubits


4. Financials (Q1 2025)

  • Revenue: $21.4 million (YoY growth of 105%)

  • 2025 Full-Year Revenue Guidance: $85.4 million

  • Cash Position: ~$450 million

  • EBITDA: -$39 million (expected to improve with enterprise sales)

  • R&D Spend: $80M/year (focused on scale and networking)


5. Market Opportunity

Quantum Computing TAM:

  • Estimated to exceed $65B by 2035

  • Applications: Pharma, finance, logistics, materials, aerospace

Quantum Internet:

  • Projected to be a $100B+ market by 2040

  • Applications: Unhackable communication, distributed computing, secure financial networks

IonQ is among the only public companies actively developing quantum networking hardware and protocols.


6. Investment Thesis

Strengths:

  • First-mover advantage in trapped-ion hardware

  • Exclusive access via major cloud platforms

  • Strong government and enterprise backing

  • IP moat via ID Quantique, Qubitekk, and internal R&D

  • Scalable architecture suited for quantum internet nodes

Risks:

  • Capital burn still high

  • Quantum networking standards still in development

  • Competition from private giants (e.g., Quantinuum, PsiQuantum)


7. Analyst Sentiment

  • Average Price Target (2025): $40

  • Consensus: Buy

  • Bull Case: IonQ leads quantum internet build-out, captures government & defense network deals

  • Bear Case: Slower-than-expected commercialization; rising competition


8. Conclusion

IonQ is not only a premier quantum computing stock but also a potential linchpin of the future quantum internet. 

Its blend of scalable hardware, photon-based communication R&D, strategic acquisitions like Qubitekk and ID Quantique, and integration with global cloud services positions it as a unique long-term investment in deep tech and next-gen networking.

Investment Rating: Overweight (Long-Term Growth-Oriented)


IONQ is moving fast to position itself at the forefront of a Quantum Internet!