As NTLA's phase 3 trials continue to show signs of real breakthroughs, there may eventually be takeover offers. (Speculation)
Full disclosure: We are long NTLA!
Intellia Therapeutics (NTLA) — Investor Brief (Aug 2025)
What They Do
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Leader in CRISPR gene editing.
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Focused on one-time treatments for serious diseases, using lipid nanoparticles (LNPs) to deliver CRISPR directly into the body.
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First company to show human proof that CRISPR can work safely in vivo (inside the body).
Key Drugs in Development
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nex-z (ATTR Amyloidosis)
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Targets a deadly heart and nerve disease.
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In Phase 3 trials now.
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Competes with Pfizer (tafamidis), BridgeBio (acoramidis), and Alnylam (Amvuttra).
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Big advantage if proven: a single treatment vs. lifelong pills/injections.
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lonvo-z (HAE – Hereditary Angioedema)
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Rare, painful swelling disorder.
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In Phase 3 trials, with FDA filing expected in 2026.
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Current drugs (Takeda’s Takhzyro, CSL’s Andembry) require regular injections. Intellia aims for a one-time permanent fix.
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Partnerships
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Regeneron: Co-develops ATTR drug, but keeps 25% of profits.
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Other smaller partnerships (Novartis, AvenCell) give extra validation.
Financial Snapshot (Q2 2025)
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Cash: $630M (enough into early 2027).
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Quarterly revenue: $14M (partnerships).
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Quarterly loss: $101M (normal for biotech).
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Shares: ~105M.
Why It Matters
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ATTR market: Pfizer’s tafamidis alone made $5.4B in 2024.
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HAE market: Already over $1B+ yearly and growing.
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If Intellia succeeds, these are multi-billion dollar markets with limited competition for one-time cures.
Potential Buyers
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Regeneron: Most likely buyer (already partner, would keep all ATTR profits).
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Takeda: HAE leader; may want to defend franchise.
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CSL: Just launched a new HAE drug but could be disrupted.
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Pfizer: ATTR giant, could buy to protect tafamidis sales.
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Other big pharma (AstraZeneca, Roche, GSK) could also step in.
Buyout Scenarios
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Current stock price: ~$11–12/share.
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If late-stage trials succeed, potential takeout offers could land $28–$57/share (150%–400% upside).
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Upside comes from:
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Clear Phase 3 wins.
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Big Pharma wanting to protect/expand rare disease franchises.
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Intellia being one of the few with proven in-body CRISPR results.
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Risks
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Competition is fierce: ATTR already has 3 approved drugs.
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Payers/insurance: One-time therapy pricing will face tough negotiations.
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Cash burn: Enough until 2027, but commercialization will need more funding.
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Profit share: ATTR economics partly belong to Regeneron.
Bottom Line
Intellia sits at the intersection of category-defining technology and late-stage assets in two sizable rare-disease markets. With clear Phase 3 wins, especially in HAE and ATTR-CM, we think (i) Regeneron is the most logical acquirer (economics synergy), with Takeda and CSL plausible strategic bidders given franchise logic; and (ii) a reasonable buyout range would center around $28–$57/share, skewing higher if both programs hit convincingly and a strategic (vs. financial) buyer leads the process.
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Intellia is high-risk, high-reward.
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